Third-hand smoke can trigger cancer

Leftover cigarette smoke that clings to walls and furniture could pose a serious health threat to young children who put toys into their mouths.

An ongoing research in the US claims that one compound from this ""third-hand smoke"" damages DNA and sticks to it in a way that could potentially cause cancer. The researcher, Bo Hang from the Lawrence Berkeley National Laboratory, made a presentation of his study at the 247th National Meeting & Exposition of the American Chemical Society (ACS) in Dallas last week.

Around 4,000 compounds in second-hand smoke, which wafts through the air as a cigarette is smoked, can linger indoors. Scientists from the Berkeley laboratory found such substances can react with indoor pollutants such as ozone and nitrous acid, creating brand-new compounds, that may be carcinogenic.

Hang is researching one such compound called NNA, a tobacco-specific nitrosamine. It locks onto DNA to form a bulky adduct (a piece of DNA bound to a cancer-causing chemical), as well as other adducts, in lab test tubes. Other large compounds that attach to DNA tend to cause genetic mutations. NNA also breaks the DNA about as often as a related compound called NNK, which is a well-studied byproduct of nicotine and a known potent carcinogen. This kind of DNA damage can lead to uncontrolled cell growth and the formation of cancerous tumors,'' said a press release sent by the American Chemical Soceity.

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